產品介紹

ω-agatoxin IVA / Omega agatoxin IVA(ω-漏斗網蛛毒素 IVA)

Blocker of P/Q-type calcium channel (Ca_v2.1)

P/Q型鈣離子通道(Ca_v2.1)阻斷劑

ω-agatoxin IVA (ω-AGA IVA) is a peptide originally isolated from funnel web-spider venom Agelenopsis aperta. This peptide is a specific blocker of P/Q-type calcium channel (Ca_v2.1). It has been reported that ω-agatoxin IVA is a potent blocker of voltage-gated calcium channels in insect and vertebrate central neurons. The binding site for ω-agatoxin IVA has been localized in part to the extracellular S3–S4 loop in repeat IV of the α-_1A Ca2⁺ channels, which is proximal to the S4 sensor domain. This is coherent with its functional effect (no pore-blocking activity, but gating modifier by a shift of channel activation towards more depolarized potentials). This makes this toxin a voltage-dependent blocker of P/Q calcium channels.

ω-agatoxin IVA(ω-漏斗網蛛毒素 IVA)技術資料

氨基酸序列： 

Lys-Lys-Lys-Cys⁴-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys¹²-Lys-Trp-Gly-Gly-Thr-Pro-Cys¹⁹-Cys²⁰-Arg-Gly-Arg-Gly-Cys²⁵-Ile-Cys²⁷-Ser-Ile-Met-Gly-Thr-Asn-Cys³⁴-Glu-Cys³⁶-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH

二硫鍵：Cys⁴-Cys²⁰, Cys¹²-Cys²⁵, Cys¹⁹-Cys³⁶ and Cys²⁷-Cys³⁴ 

長度 (aa)： 48

分子式： C₂₁₇H₃₆₀N₆₈O₆₀S₁₀ 

分子量： 5202.48 Da

外觀：White lyophilized solid

可溶性：water and saline buffer

CAS 號： 145017-83-0 

來源：Synthetic 

純度：> 97 %

產品信息